http://burnhamott.technologypublisher.comBe the first to know about the latest inventions and technologies available from Burnham Instituteen-USThu, 29 Jul 2010 13:15:58 GMTThu, 03 Jun 2010 11:33:54 GMThttp://blogs.law.harvard.edu/tech/rssccurchoe@burnham.orgCopyright 2010, Burnham Institutehttp://burnhamott.technologypublisher.com/technology/5283 Biologicals           Aging - Diabetes - Metabolic Diseases - Stem Cell Biology - Therapeutics   The current invention provides methods of modulating the insulin/IGF pathway to treat symptoms related to aging. Features ·         Reduces symptoms of aging Background Glucose and lipid homeostasis is maintained in higher organisms through the insulin/IGF ...]]>Thu, 03 Jun 2010 11:33:54 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/5283http://burnhamott.technologypublisher.com/technology/5230 Small Molecule Compounds                                                  Neurobiology - Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a partner to commercialize novel positive allosteric modulators of mGluR2 for the treatment of neurological d...]]>Wed, 19 May 2010 15:51:05 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/5230http://burnhamott.technologypublisher.com/technology/5207 Biologics           Diabetes - Immunology -  Infectious Diseases - Therapeutics   Features The Sanford-Burnham Medical Research Institute is seeking a partner to commercialize methods of modulating the CD44 pathway to treat immune and autoimmune disorders.     Background Memory T cells are a subset of T cells that persist long after an infection has occurred. Optimal immunity depends on the reg...]]>Mon, 17 May 2010 16:36:40 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/5207http://burnhamott.technologypublisher.com/technology/5090 Peptides                                            Diagnostics - Therapeutics     Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References List of references via Pubmed   Patent Inform...]]>Mon, 03 May 2010 13:35:43 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/5090http://burnhamott.technologypublisher.com/technology/4885 Small Molecule Compounds                                     Apoptosis - Cancer - Therapeutics   Background Adamantyl-substituted retinoid related molecules are a unique class of compounds which have been found to induce apoptosis, or cell death, in many different tumor types. Currently, there is an unmet medical...]]>Wed, 07 Apr 2010 10:22:12 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/4885http://burnhamott.technologypublisher.com/technology/4771 Stem Cell Biology             Features ·    Enhances IPS cell generation efficiency ·         Can direct differentiation of IPS cells   Background Induced pluripotent stem cells are very similar to embryonic stem cells and were originally generated by over expression of four nuclear reprogramming factors; Oct4, Sox2, Klf4 and cMyc. Many cell types...]]>Tue, 23 Mar 2010 11:46:13 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/4771http://burnhamott.technologypublisher.com/technology/4652 Peptides                                                Cancer - Therapeutics   Peptides that bind EphB receptors, disrupting receptor-ligand interactions, to modulate the activity of EphB receptors and stimulate apoptosis.   Background The Eph receptors ar...]]>Fri, 12 Feb 2010 12:16:11 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/4652http://burnhamott.technologypublisher.com/technology/4651 Peptides                                                Cancer - Therapeutics   Tumor targeting peptides that can bind to cellular carbohydrate sequences.   Background A major obstacle in treating cancer is the relative lack of agents that can selective...]]>Fri, 12 Feb 2010 10:57:22 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/4651http://burnhamott.technologypublisher.com/technology/4345 Small Molecule Compounds                                          Neurobiology - Therapeutics   Background The Eph receptors are best known for their role in the developing and injured nervous system and in the developing cardiovascular system, but have recently been implicated in insulin secretion ...]]>Tue, 15 Dec 2009 16:55:41 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/4345http://burnhamott.technologypublisher.com/technology/4344 Assays           Cardiovascular Disease - Therapeutics   Cardiac arrhythmia and sudden cardiac death are major pharmaceutical targets from therapeutic and toxicologic standpoints. Recently, several cardiac drugs have been withdrawn from the market or restrictively labeled due to toxicology concerns.  Additionally, withdrawal from clinical trials of late stage cardiac drugs can cause severe financial losses. A method for identifying new ...]]>Tue, 15 Dec 2009 13:51:37 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/4344http://burnhamott.technologypublisher.com/technology/4343 Biologics                                             Infectious Diseases - Therapeutics West Nile virus (WNV) is transmitted to humans from mosquito bites and can have varied effects ranging from asymptomatic infections to a neuroinvasive form called West Nile meningitis, which can be deadly. The...]]>Tue, 15 Dec 2009 13:51:37 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/4343http://burnhamott.technologypublisher.com/technology/4279 Biologics                                                Cancer - Therapeutics   BackgroundKaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8, is associated not only with B-lymphoproliferative diseases such as primary effusion lymphoma, but also wi...]]>Mon, 14 Dec 2009 12:41:46 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/4279http://burnhamott.technologypublisher.com/technology/3554 Nanoparticle                                                Cancer - Therapeutics   Background Nanomedicine is an emerging field that uses nanoparticles to facilitate the diagnosis and treatment of diseases.  Nanoparticles are attractive because multiple functions can be bui...]]>Thu, 29 Oct 2009 16:06:40 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3554http://burnhamott.technologypublisher.com/technology/3503 Small Molecule Compounds           Apoptosis - Cancer - Therapeutics   The current invention provides compounds or retinoid and non retinoid analogues (3-cl-AHPN) to induce apoptosis in cancer cells.   Features ·        Induces apoptosis in the M07e human leukemic megakaryocytic and patient derived leukemic cell lines Background Retinoid related molecules are a ...]]>Fri, 09 Oct 2009 14:54:17 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3503http://burnhamott.technologypublisher.com/technology/3502 Peptides                                              Cancer - Therapeutics   Synthetic peptides to inhibit cell migration or invasion.   Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References Li...]]>Fri, 09 Oct 2009 14:54:14 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3502http://burnhamott.technologypublisher.com/technology/3501 Biologics          Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References List of references via Pubmed   Patent Information Click here for patent   Full title: Methods for Modifying the Binding of Cell Adhesion Receptors Patent/Application #:  5,759,855 Priority date: 9-14-1998 Foreign filing: ye...]]>Fri, 09 Oct 2009 14:54:14 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3501http://burnhamott.technologypublisher.com/technology/3500 Biologics          Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References List of references via Pubmed Patent Information Click here for patent   Full title: Cooperative Combinations of Ligands Contained within a Matrix Patent/Application #:  5,830,504 Priority date: 12-20-1998 Foreign filing: yes Burnham ID: 88-5 ...]]>Fri, 09 Oct 2009 14:54:14 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3500http://burnhamott.technologypublisher.com/technology/3499 Biologics Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage Selected References List of references via Pubmed Patent Information Click here for patent   Full title: Antibodies to Integrins Patent/Application #:  5,700,908 Priority date: 6-1-1995 Foreign filing: yes Burnham ID: 89-1   Status Available for license   ]]>Fri, 09 Oct 2009 14:54:13 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3499http://burnhamott.technologypublisher.com/technology/3498 Biologics Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References List of references via Pubmed Patent Information Click here for patent   Full title: Inhibiting Transforming Growth Factor beta to Prevent Accumulation of Extracellular Matrix Patent/Application #:  7,214,375 Priority date: 9-29-1989 Foreign filing: yes Burnham ID: 89-4   Status ...]]>Fri, 09 Oct 2009 14:54:13 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3498http://burnhamott.technologypublisher.com/technology/3497 Biologics          Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References List of references via Pubmed Patent Information Click here for patent Full title: Method for detection of fibronectin receptor ligands Patent/Application #:  5,591,592 Priority date: 1-5-1990 Foreign filing: yes Burnham ID: ...]]>Fri, 09 Oct 2009 14:54:13 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3497http://burnhamott.technologypublisher.com/technology/3496 Biologics                                                    Cancer - Therapeutics The current invention provides soluble and membrane-bound forms of human .beta.-1,6-N-acetylglucosaminyltransferase,an I-branching enzyme (IGnT) implicated in the  regulation ...]]>Fri, 09 Oct 2009 14:54:12 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3496http://burnhamott.technologypublisher.com/technology/3495 Biologics                                             Cancer - Therapeutics E-selectin mediated cell adhesion antagonists for controlling inflammation and metastasis.   Lead Inventor Michiko Fukuda, Ph.D. Fukuda lab homepage   Selected References ...]]>Fri, 09 Oct 2009 14:54:11 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3495http://burnhamott.technologypublisher.com/technology/3488 Biologics                          Biomarker - Cancer - Therapeutics Uses of EGFr as a diagnostic and prognostic biomarker in microsatellite instability positive gastroinestinal tumors. Features Improves the specificity of colon cancer treatments Background Microsatellite instability tumors display a mismatch repair mutator phenotype allo...]]>Thu, 01 Oct 2009 14:52:18 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3488http://burnhamott.technologypublisher.com/technology/3486Wed, 30 Sep 2009 16:53:04 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3486http://burnhamott.technologypublisher.com/technology/3469 Small Molecule Compounds           Cancer - Cardiovascular Disease - Infectious Disease - Therapeutics   Background HNF4a is a member of the nuclear receptor family found only in the pancreas, liver, kidney, colon, small intestine and testes. HNF4a has been implicated in many diseases including, diabetes, cancer, hepatitis, hemophilia, thrombosis and atherosclerosis. The current invention provides HNF4a antagonist compounds for the t...]]>Tue, 29 Sep 2009 11:24:04 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3469http://burnhamott.technologypublisher.com/technology/3468 Biologics           Cardiovascular Disease - Therapeutics - Thrombosis Targeting the clot-binding peptide CREKA protein with surfactant containing micelles for the treatment of atherosclerotic plaques.   Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References List of references via Pubmed   Patent In...]]>Tue, 29 Sep 2009 11:21:28 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3468http://burnhamott.technologypublisher.com/technology/3467 Nanoparticles                                   Cancer - Therapeutics   A nanoparticle delivery system where the particles amplify their own homing by a modified clot-binding compound that can selectively bind to clotted plasma protein.   Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage...]]>Tue, 29 Sep 2009 11:21:28 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3467http://burnhamott.technologypublisher.com/technology/3345Thu, 20 Aug 2009 17:20:54 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3345http://burnhamott.technologypublisher.com/technology/3344 Peptides                                   Cancer - Diagnostics - Therapeutics   Bladder epithelium targeting peptides for the treatment of cancer   Features   ·         Non-invasive bladder cancer diagnostic tool ·       &n...]]>Thu, 20 Aug 2009 17:07:56 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3344http://burnhamott.technologypublisher.com/technology/3343 Stem Cell Biology                                 Biomarker - Diabetes - Therapeutics   A marker of endocrine stem/progenitor cells, Hes6, that can differentiate glucose responsive insulin secreting cells for diabetes disease research and therapies.   Features ·       &nbs...]]>Thu, 20 Aug 2009 17:01:29 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3343http://burnhamott.technologypublisher.com/technology/3342Thu, 20 Aug 2009 17:01:28 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3342http://burnhamott.technologypublisher.com/technology/3341Thu, 20 Aug 2009 17:01:28 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3341http://burnhamott.technologypublisher.com/technology/3319 Diagnostics                                     Cancer - Therapeutics   Expression and cellular localization of the tumor supressor gene, ATF2, as a diagnostic and therapeutic target for melanomas.   Features ·        The ability to improve diagnosis and therapy for m...]]>Mon, 17 Aug 2009 16:53:24 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3319http://burnhamott.technologypublisher.com/technology/3318 Small Molecule Compounds           Cancer - Therapeutics   Features ·         JNK is inhibited strongly and selectively ·         Cancer, inflammation and neurodegenerative disorder therapy   Background Protein kinases are families of enzymes that catalyze the phosphorylation of specific residues in proteins and ...]]>Mon, 17 Aug 2009 16:53:24 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3318http://burnhamott.technologypublisher.com/technology/3317 Small Molecule Compounds           Cancer - Immunology and Inflammation - Therapeutics   Thiosesterase inhibitors for the treatment of cancer.   Features · Inhibits thioesterase activity of the human fatty acid synthase · Can treat a wide variety of diseases including cancer, inflammation, autoimmune diseases and bacterial infections   Backgro...]]>Mon, 17 Aug 2009 16:53:23 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3317http://burnhamott.technologypublisher.com/technology/3316 Assays           Apoptosis - Cancer - Therapeutics   A small molecule screening method for proapoptotic Bcl-2 converters.   Features ·        Converts Bcl-B from anti-apoptotic to a pro-apoptotic   Background Programmed cell death, or apoptosis, allows organisms to eliminate unwanted cells, such as during normal embryonic development and after a...]]>Mon, 17 Aug 2009 16:53:23 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3316http://burnhamott.technologypublisher.com/technology/3315 Assays           Cancer  - Cardiovascular Disease - Neurobiology   GST fusion proteins conjugated with GFP for use in a throughput flow cytometry assays for the analysis of glutathiones and their binding partners. Features ·         High throughput format Background Glutathione is a ubiquitous tri-peptide that can be oxidized; it is the major redox couple in animal cells....]]>Mon, 17 Aug 2009 16:53:22 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3315http://burnhamott.technologypublisher.com/technology/3313 Small Molecule Compounds                                                            Cancer   Compounds that inhibit VHR for the treatment of diseases characterized by VHR dysregulation, such as cancer.   ...]]>Mon, 17 Aug 2009 11:26:39 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3313http://burnhamott.technologypublisher.com/technology/3292 Small Molecule Compounds           Apoptosis - Cancer - Therapeutics     Compounds that modulate retinoid X receptor transport from the nucleus to the cytoplasm of a cell, to induce apoptosis for the treatment of cancer and autoimmune disorders.   Lead Inventor Xiao-kun Zhang, Ph.D. Zhang lab homepage   Selected References Cao, X., et al. 2004. Mol ...]]>Fri, 14 Aug 2009 13:28:14 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3292http://burnhamott.technologypublisher.com/technology/3289 Peptides                                        Apoptosis - Cancer- Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing a novel method of inducing cell death in cancerous cells. Researchers at Sanford-Burnham have discovered peptides that mimic the ...]]>Fri, 14 Aug 2009 10:58:17 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3289http://burnhamott.technologypublisher.com/technology/3284 Small Molecule Compounds           Apoptosis - Cancer- Immunology and Inflammation - Therapeutics   Compounds that inhibit BID a BCL-2 family member for the treatment of cell death disorders.   Features ·         Caspase activity can be modulated ·         BID is inhibited, preventing cell death   Background T...]]>Wed, 12 Aug 2009 11:41:59 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3284http://burnhamott.technologypublisher.com/technology/3283 Peptides                                       Apoptosis - Cancer - Therapeutics   A melanoma specific apoptosis inducing chimeric peptide for the inhibition of Caspase-9 to treat cancer.   Lead Inventor Guy Salvesen, Ph.D. Salvesen lab homepage   Selected Reference...]]>Wed, 12 Aug 2009 11:41:58 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3283http://burnhamott.technologypublisher.com/technology/3282 Small Molecule Compounds           Immunology and Inflammation - Infectious Diseases - Therapeutics   Intestinal alkaline phosphatase modulators for the treatment of bacterial infections, inflammation and scarring of the gut, such as occurs with Crohn’s disease.   Lead Inventor José Luis Millán, Ph.D. Millán lab homepage    Selected References Proc Natl...]]>Wed, 12 Aug 2009 11:41:58 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3282http://burnhamott.technologypublisher.com/technology/3281 Stem Cell Biology                                                   Neurobiology   Materials and methods for the differentiation of neural  stem cells and neural tube like structures from human stem cells. Lead Inventor Evan Snyder ...]]>Wed, 12 Aug 2009 11:41:58 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3281http://burnhamott.technologypublisher.com/technology/3280 Peptides                                                 Apoptosis - Immunology   Peptides of CD40 associated proteins (CAP) for the treatment or diagnosis of diseases characterized by aberrant CD40 expression, such as X linked immunodeficiency syndrome.   ...]]>Wed, 12 Aug 2009 11:41:57 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3280http://burnhamott.technologypublisher.com/technology/3257 Stem Cell Biology                                              Cell culture - Defined media Chemically defined, minimal culture media for pluripotent and human embryonic stem cells. Background Stem cells are cells capable of differentiation into many cell types. Human embr...]]>Tue, 11 Aug 2009 14:53:12 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3257http://burnhamott.technologypublisher.com/technology/3235Thu, 23 Jul 2009 12:53:22 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3235http://burnhamott.technologypublisher.com/technology/3234 Peptides                                           Apoptosis - Cancer - Therapeutics   Tissue selective homing peptides containing CENDR and iRDG elements to enhance internalization and penetration of compounds, for the treatment of cancer.   Features Targetin...]]>Thu, 23 Jul 2009 12:53:22 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3234http://burnhamott.technologypublisher.com/technology/3152 Peptides                                               -  Immunology -   Peptides of a macrophage and B cell specific transcriptional activator, PU.1, for use in identifying cell specific transcription regulators. Lead InventorRichard Maki, Ph.D.   ...]]>Mon, 06 Jul 2009 14:22:27 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3152http://burnhamott.technologypublisher.com/technology/3151 Peptides           Peptides of merosin, an isoform of laminin, for cell adhesion applications.   Lead InventorEva Engvall, Ph.D., M.D.H.C.Engvall lab homepage   Selected ReferencesMatrix. 1991 Jun;11(3):151-60. Haaparanta, T. et al.   Patent Information Click here for patent   Full title: Merosin, Nucleic Acids Encoding Fragments and Uses thereof (Heteromeric Variants of Laminin Lik...]]>Mon, 06 Jul 2009 14:22:26 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3151http://burnhamott.technologypublisher.com/technology/3150 Biologics          A method of obtaining homogeneous recombinant calf alkaline phosphatase.   Lead Inventor José Luis Millán, Ph.D. Millán lab homepage   Selected References Biochem J. (1993) 290, 503-508 Weissig, H. et al.   Patent Information Click here for patent   Full title: Recombinant Calf Intestinal Alkaline ...]]>Mon, 06 Jul 2009 14:22:26 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3150http://burnhamott.technologypublisher.com/technology/3141 Biologics                            Cancer - Therapeutics Methods of regulating hyperproliferative cells by introducing adenovirus E1A activity. Lead InventorSteven Frisch, Ph.D. Selected ReferencesClick here for references   Patent Information Click here for patent   Full title...]]>Thu, 02 Jul 2009 12:25:22 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3141http://burnhamott.technologypublisher.com/technology/3140 Assays           Therapeutics   A method of preventing homodimerization of retinoid X receptors and ablating the DNA transcription mediated by retinoid X receptors.   Lead InventorMagnus Pfahl, Ph.D.   Selected References Nature. 1992 Aug 13;358(6387):587-91. Zhang, XK. et  al.   Patent Information Click here for patent   ...]]>Thu, 02 Jul 2009 12:25:22 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3140http://burnhamott.technologypublisher.com/technology/3139 Peptides                                                      Therapeutics   Peptides specific for fibronectin and vitronectin binding integrins to modulate cell adhesion.   Lead Inventor Erkki Ruoslahti, M.D., Ph...]]>Thu, 02 Jul 2009 12:25:21 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3139http://burnhamott.technologypublisher.com/technology/3138 Peptides                                               Reproduction - Cancer   Peptides of trophinin, an apical cell adhesion mediating protein, for use in cancer and reproduction studies.   Lead Inventor Michiko Fukuda, Ph.D. Fukud...]]>Thu, 02 Jul 2009 12:25:21 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3138http://burnhamott.technologypublisher.com/technology/3137 Peptides                                                  Cancer - Therapeutics   A method of enhancing cancer treatments by sensitizing tumor cells with peptides encoding adenovirus E1A.   Lead InventorSteven Frisch, Ph.D.   Selected...]]>Thu, 02 Jul 2009 12:25:21 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3137http://burnhamott.technologypublisher.com/technology/3136 Peptides                                      Apoptosis - Cancer - Therapeutics   Peptides of Fas associated proteins, a member of the tumor necrosis factor receptor (TNFR) family of proteins, to modulate apoptosis.   Lead Inventor John C. Reed, M.D., Ph.D. Reed lab homepage ...]]>Thu, 02 Jul 2009 12:25:20 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3136http://burnhamott.technologypublisher.com/technology/3118 Peptides                                             Cancer - Therapeutics   Peptides of the Rb-interacting zinc finger (RIZ) protein and a conserved domain of a RIZ protein that is involved in regulating gene transcription for controlling cell proliferation and differentiation.   ...]]>Mon, 29 Jun 2009 10:53:27 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3118http://burnhamott.technologypublisher.com/technology/3117 Biologics                                                          Neurobiology Isolation and characterization of polysialic acid (PSA), a molecule that is added to the neural cell adhesion molecule, NCAM, for the modulation of norm...]]>Mon, 29 Jun 2009 10:53:27 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3117http://burnhamott.technologypublisher.com/technology/3116 Assays             A method to identify organ homing peptides.   Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References List of references via Pubmed Patent Information Click here for patent   Full title: Method of Identifying Molecules that Home to a Selected Organ In Vivo U.S. Patent/Application #: 7,341,710 ...]]>Mon, 29 Jun 2009 10:53:27 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3116http://burnhamott.technologypublisher.com/technology/3115 Peptides                                                       Therapeutics   Peptides that home to target organs to deliver a drug or therapeutics.     Lead Inventor Erkki Ruoslahti, M.D., Ph.D. ...]]>Mon, 29 Jun 2009 10:53:26 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3115http://burnhamott.technologypublisher.com/technology/3114 Peptides           Bone Disorders - Cancer - Immunology and Inflammation - Thrombosis   Cyclic peptides that mimic the integrin site to modulate the activities of RGD-binding integrins to reduce or inhibit cell attachment.   Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References List of references via Pubmed Patent Information ...]]>Mon, 29 Jun 2009 10:53:25 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3114http://burnhamott.technologypublisher.com/technology/3113 Peptides                                               Cancer - Therapeutics   Peptides that home to the vasculature of tumors to treat cancer.   Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References ...]]>Mon, 29 Jun 2009 10:53:25 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3113http://burnhamott.technologypublisher.com/technology/3101 Biologics                                                   Cancer - Therapeutics A method of treating tumor growth or metastasis using Superfibronectin to mediate integrin-ligand receptor binding. Lead Inventor Renata Pasqualini, Ph.D. Patent Information Clic...]]>Wed, 24 Jun 2009 16:27:34 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3101http://burnhamott.technologypublisher.com/technology/3100 Peptides                                                         Immunology   Purified human thyroid hormone receptor to diagnose or treat disorders of the thyroid system.   Lead InventorMagnus Pfahl, Ph.D.  ...]]>Wed, 24 Jun 2009 16:27:33 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3100http://burnhamott.technologypublisher.com/technology/3099 Peptides           Neurobiology - Therapeutics   Peptides of acetyl-coenzyme A transporter (AT) to diagnose physiological disorders that result from abnormal levels or abnormal structures of the AT protein.   Lead InventorMinoru Fukuda, Ph.D.Fukuda lab homepage   Selected ReferencesClick here for references   Patent Information Click here for patent   Full title: ...]]>Wed, 24 Jun 2009 16:27:33 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3099http://burnhamott.technologypublisher.com/technology/3098 Peptides                                                         Reproduction   Peptides of trophinin and related proteins to inhibit or augment embryo implantation.   Lead Inventor Michiko Fuk...]]>Wed, 24 Jun 2009 16:27:32 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3098http://burnhamott.technologypublisher.com/technology/3088 Peptides           Apoptosis - Cancer - Neurobiology - Therapeutics   Peptides of Bax (a pro-apoptotic member of the Bcl-2 family) inhibitor proteins to modulate apoptosis.   Background Members of the Bcl-2 family of proteins are crucial regulators of programmed cell death or apoptosis. This family of proteins includes both anti-apoptotic molecules such as Bcl-2 and Bcl-XL, and pro-apoptotic molecules such as Bax...]]>Tue, 23 Jun 2009 16:31:24 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3088http://burnhamott.technologypublisher.com/technology/3087 Biologics                                  Cardiovascular Disease - Therapeutics A method of disrupting integrin receptor-ligand interactions, such as a platelet thrombus in a blood vessel during cardiovascular disease processes. Lead InventorJeffrey Smith, Ph.D.Smith lab homepage Selected References Methods Cell Biol. 2002;69:24...]]>Tue, 23 Jun 2009 16:31:23 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3087http://burnhamott.technologypublisher.com/technology/3086 Peptides              Cancer - Immunology and Inflammation - Infectious Diseases -  Therapeutics   Polypeptides displaying poly-N-acetyllactosamine sugar chain synthesis-related activities for use as an anti-inflammatory or anti-cancer agent.   Lead InventorMinoru Fukuda, Ph.D.Fukuda lab homepage   Selected ReferencesProc Natl Acad Sci U S A. 1997 Dec 23;94(26):14294-9. Sasaki, K. et...]]>Tue, 23 Jun 2009 16:31:23 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3086http://burnhamott.technologypublisher.com/technology/3085 Biologics                                     Cancer - Diagnostics - Therapeutics Peptides that selectively home to tissues and can diagnose or treat various pathologies, such as cancer.   Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected Refer...]]>Tue, 23 Jun 2009 16:31:22 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3085http://burnhamott.technologypublisher.com/technology/3084 Peptides                                                Cancer - Therapeutics   Peptides that home to tumor vasculature to treat cancer.   Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected Refer...]]>Tue, 23 Jun 2009 16:31:22 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3084http://burnhamott.technologypublisher.com/technology/3083 Biologics                                       Apoptosis - Cancer - Therapeutics The family of Bag-1 related proteins (regulators of protein folding) and nucleic acids that encode them for use as anticancer agents.   Lead Inventor John C. Reed, M.D., Ph.D. Reed lab homepage   ...]]>Tue, 23 Jun 2009 16:31:21 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3083http://burnhamott.technologypublisher.com/technology/3082 Peptides           Apoptosis - Signal Transduction - Therapeutics   Peptides of proapoptotic dependence domains for the modulation of apoptosis.   Lead InventorDale Bredesen, M.D.   Selected ReferencesJ Mol Neurosci. 2000 Dec;15(3):215-29.  Rabizadeh, S. et al.   Patent Information Click here for patent   Full title: Proapoptotic Peptides, Depend...]]>Tue, 23 Jun 2009 16:31:21 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3082http://burnhamott.technologypublisher.com/technology/3081 Biologics                     Cancer - Immunology & Inflammation - Therapeutics Antibodies to the vitronectin receptor for the treatment of tumor metastasis, solid tumor growth (neoplasia) and other disorders. Lead InventorJeffrey Smith, Ph.D.Smith lab homepage   Patent Information Click here for patent   Full title...]]>Tue, 23 Jun 2009 16:31:21 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3081http://burnhamott.technologypublisher.com/technology/3077 Peptides                   Cancer - Immunolgy and Inflammation - Therapeutics   Peptides to identify and characterize members of the glycosyltransferase enzyme family, implicated in pathological conditions such as inflammation, tissue rejection and tumor metastasis.   Lead InventorMinoru Fukuda, Ph.D.Fukuda lab homepage   Selected ReferencesClick here for ref...]]>Mon, 22 Jun 2009 16:46:30 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3077http://burnhamott.technologypublisher.com/technology/3076 Biologics                                                     Cancer - Therapeutics Methods of inhibiting tumor metastasis by blocking the interaction of selectins (cell surface carbohydrates). Lead Inventor Michiko Fukuda, Ph.D. Fukuda lab homepage ...]]>Mon, 22 Jun 2009 16:46:30 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3076http://burnhamott.technologypublisher.com/technology/3075 Peptides                                            Cancer - Therapeutics   Peptides that can home to angiogeneic vasculature for the treatment of cancer.   Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References ...]]>Mon, 22 Jun 2009 16:46:30 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3075http://burnhamott.technologypublisher.com/technology/3073 Assays            Cancer - Diagnsostics   Methods for determining a prognosis in cancer patients by measuring the Bcl-2 family member, BAG-1, protein levels.   Lead Inventor John C. Reed, M.D., Ph.D. Reed lab homepage   Selected References Kudoh, M. et al. Cancer Res. 2002 Mar 15;62(6):1904-9.   Patent Information Full title: A Method for Deter...]]>Mon, 22 Jun 2009 16:46:29 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3073http://burnhamott.technologypublisher.com/technology/3072 Peptides                                    Cardiovascular Disease - Therapeutics   Peptides that home to cardiac tissue for the treatment of cardiac disease.   Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References List of references via ...]]>Mon, 22 Jun 2009 16:46:29 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3072http://burnhamott.technologypublisher.com/technology/3071 Peptides           Cancer - Post Translational Modifications - Therapeutics   Peptides of siah-mediated-degradation-proteins (SMDPs) involved in protein degradation pathways for the treatment of disorders characterized by aberrant protein degradation, such as cancer.   Lead Inventor John C. Reed, M.D., Ph.D. Reed lab homepage   Selected References List of references via Pubmed &nbs...]]>Mon, 22 Jun 2009 16:46:29 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3071http://burnhamott.technologypublisher.com/technology/3070 Peptides                        Apoptosis  - Cancer - Diagnostics  - Therapeutics   Peptides containing caspase recruitment domains (CARD) and ATP-binding oligomerization domains (NB-ARC) for manipulating cellular apoptosis and treating cell death disorders, such as cancer.   Lead Inventor John C. Reed, M.D., Ph.D. Reed lab homepage &nb...]]>Mon, 22 Jun 2009 16:46:29 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3070http://burnhamott.technologypublisher.com/technology/3069 Peptides                          Apoptosis - Cancer - Diagnostics -  Therapeutics   Peptides of Bcl-G, a member of the Bcl-2 family of proteins, for the modulation of programmed cell death to treat cancer and other cell proliferation disorders.   Lead Inventor John C. Reed, M.D., Ph.D. Reed lab homepage   Selected ...]]>Mon, 22 Jun 2009 16:46:28 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3069http://burnhamott.technologypublisher.com/technology/3068 Small Molecule Compounds                                           Bone Disorders - Therapeutics   Compounds that inhibit tissue non-specific alkaline phosphatase (TNAP) to treat bone mineralization disorders.   Lead Inventor José Luis Millán, Ph.D. Millá...]]>Mon, 22 Jun 2009 16:46:28 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3068http://burnhamott.technologypublisher.com/technology/3064 Biologics           The fibronectin receptor and methods of targeting liposomes to tissues containing fibronectin receptors.   Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References List of references via PubmedPatent Information Click here for patent   Full title: Isolation and Use of Fibronectin Receptor ...]]>Thu, 18 Jun 2009 16:52:44 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3064http://burnhamott.technologypublisher.com/technology/3063 Biologics           Methods of isolating cell surface receptors for inclusion into liposomes to target specific tissues.   Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References List of references via Pubmed Patent Information Click here for patent   Full title: Isolation and Use of Receptors Binding to a Peptide ...]]>Thu, 18 Jun 2009 16:52:43 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3063http://burnhamott.technologypublisher.com/technology/3062 Peptides                                                     Therapeutics   Peptides that are stereochemically constrained in conformations that allow specific binding of cell adhesion receptors for example, vitronectin in favor of fibronectin, for cell adhes...]]>Thu, 18 Jun 2009 16:52:43 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3062http://burnhamott.technologypublisher.com/technology/3061 Assays           Apoptosis - Cancer - Therapeutics   Methods of identifying and interrupting interactions among cell death proteins for the treatment of apoptosis related disorders, such as cancer.   Lead Inventor John C. Reed, M.D., Ph.D. Reed lab homepage   Selected References List of references via Pubmed   Patent Information C...]]>Thu, 18 Jun 2009 16:52:42 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3061http://burnhamott.technologypublisher.com/technology/3060Thu, 18 Jun 2009 16:52:35 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3060http://burnhamott.technologypublisher.com/technology/3059 Gene Application References Investigator NR3A NMDA receptor modulator, neuroprotection Das et al., 1998 Nakanishi et al., 2009 Lipton TNAP Infantile hypophosphatasia Narisawa et al., 1997 Millán IAP Regulation of fat absorption Narisawa et al., 2003 Millán Cyt cT Early onset testicular atrophy Narisawa et al., 2002 Millán ...Thu, 18 Jun 2009 16:52:35 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3059http://burnhamott.technologypublisher.com/technology/3057 Peptides                                 Apoptosis - Cancer - Diagnostics - Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing polypeptides that bind Survivin for the treatment of cancers where Survivin is over expressed.   Lead Inventor John C. Ree...]]>Thu, 18 Jun 2009 16:52:34 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/3057http://burnhamott.technologypublisher.com/technology/2723 Assays                                                        Signal Transduction   A method to identify, amplify and sequence genes that are being regulated by transcription factors.   Lead Investigator Eileen Adamson...]]>Wed, 10 Jun 2009 16:03:10 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2723http://burnhamott.technologypublisher.com/technology/2722 Biologics          Cardiovascular Disease - Diagnostics - Therapeutics Cardioprotective effects of adiponectin mediated by T-cadherin.   Background Adiponectin is a global regulator of metabolism and plays important roles in the cross talk between the adipose tissue and numerous organs, such as liver, brain, muscle, vasculature and the heart.  Understanding the regulation and function of adiponectin is ...]]>Wed, 10 Jun 2009 16:03:10 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2722http://burnhamott.technologypublisher.com/technology/2720 Peptides                           Apoptosis - Cancer  - Diagnostics  - Therapeutics   Polypeptides to modulate PR domain containing genes, as a way to regulate, diagnose or treat cell proliferation disorders, such as cancer.   Lead InventorShi Huang, Ph.D.Huang lab homepage   Selected ReferencesGenomics. 1999 Nov ...]]>Wed, 10 Jun 2009 16:03:08 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2720http://burnhamott.technologypublisher.com/technology/2711 Peptides                                Infectious Diseases - Therapeutics   Lead InventorAndrei Osterman, Ph.D.Osterman lab homepage   Selected ReferencesProc Natl Acad Sci U S A. 2009 Ma...]]>Fri, 05 Jun 2009 14:27:48 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2711http://burnhamott.technologypublisher.com/technology/2710 Peptides           Apoptosis - Cancer Immunology and Inflammation - Neurobiology - Therapeutics   Peptides and methods to inhibit caspases for the treatment of apoptosis related disorders, such as neurodegenerative diseases and glaucoma.   Lead InventorStuart Lipton, M.D., Ph.D.Lipton lab homepage   Selected ReferencesSeki, M. and Lipton S. A. Prog Brain Res. 2008;173:495-510.   Patent...]]>Fri, 05 Jun 2009 14:27:47 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2710http://burnhamott.technologypublisher.com/technology/2709 Small Molecule Compounds                                               Cancer - Therapeutics   Compounds of kinase inhibitors, particularly JNK, for the treatment of various diseases including cancer.   Lead Inventor Maurizio Pellecchia, Ph.D. Pellecchia lab h...]]>Fri, 05 Jun 2009 14:27:46 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2709http://burnhamott.technologypublisher.com/technology/2708 Peptides                                            Cancer - Diagnostics - Therapeutics   Eph receptor binding peptides are covalently linked to chemotherapeutic drugs to target tumors, where Eph receptors are over expressed, providing targeted drug delivery for cancer treatments. &nbs...]]>Fri, 05 Jun 2009 14:27:46 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2708http://burnhamott.technologypublisher.com/technology/2706 Software and Instruments            Continuous co-flow system for synthesis of multifuntional nano-and micro-particles.   Background Nanoparticles (NPs) with two compartments, and distinct surfaces, are called Janus particles after the mythological Roman god of gates, who is typically shown with two faces peering in opposite directions.  Most Janus particles are spherically shaped, and thus have two discernable hemi-sphere...]]>Fri, 05 Jun 2009 14:27:45 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2706http://burnhamott.technologypublisher.com/technology/2674 Assays           Glycobiology - Immunology   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel methods and kits to diagnose genetic glycosylation disorders.   Lead Inventor Hudson Freeze, Ph.D.  Freeze lab homepage   Selected References Marquardt T, Freeze H. Biol Chem. 2001 Feb;382(2):161-77. ...]]>Wed, 03 Jun 2009 16:47:50 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2674http://burnhamott.technologypublisher.com/technology/2603 Peptides                           Agriculture - Apoptosis - Cancer - Therapeutics     The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel polypeptide inhibitors of apoptosis proteins derived from the silkworm, Bombyx mori.   Lead Inventor John C. Reed, M.D., Ph.D. ...]]>Fri, 22 May 2009 16:34:31 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2603http://burnhamott.technologypublisher.com/technology/2602 Peptides           Apoptosis - Assays - Cancer - Diagnostics - Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel polypeptides containing caspase recruitment domains to modulate apoptosis and cytokine production.   Lead Inventor John C. Reed, M.D., Ph.D. Reed lab homepage   Selected References ...]]>Fri, 22 May 2009 16:30:20 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2602http://burnhamott.technologypublisher.com/technology/2601 Peptides Therapeutics - Immunology & Inflammation - Infectious Diseases   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing  novel polypeptides containing death domains (DD) and death effector domains (DED). These peptides can be used to identify apoptosis modulators for the treatment of inflammatory disorders, sepsis, autoimmune and infectious diseases.    Lead Inventor John C. R...]]>Fri, 22 May 2009 16:22:36 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2601http://burnhamott.technologypublisher.com/technology/2600 Stem Cell Biology           Neurobiology - Signal Transduction   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing a method of differentiating nervous system cells from embryonic stem cells, by modulating the MEF2C pathway, for the treatment of neurodegenerative diseases.   Lead Inventor Stuart Lipton, M.D., Ph.D.  Lipton lab homepage   S...]]>Fri, 22 May 2009 16:22:36 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2600http://burnhamott.technologypublisher.com/technology/2599 Peptides           Apoptosis - Cancer - Diagnostics - Signal Transduction - Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel polypeptides that contain and bind PAAD death domains to modulate apoptosis.   Lead Inventor John C. Reed, M.D., Ph.D. Reed lab homepage   Selected References J Biol Chem. 20...]]>Fri, 22 May 2009 16:22:36 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2599http://burnhamott.technologypublisher.com/technology/2598 Peptides           Assays - Cancer - Diagnostics - Therapeutics - Biomarker   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel methods of inhibiting microsatellite instability (MI) positive tumors with polypeptides of the tumor suppressor gene, RIZ1.   Lead InventorShi Huang, Ph.D.The Huang Lab   Selected ReferencesList of references via Pu...]]>Fri, 22 May 2009 16:22:36 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2598http://burnhamott.technologypublisher.com/technology/2596 Peptides                     Apoptosis - Assays - Cancer - Diagnostics - Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing a novel apoptosis modulator, Bcl-B, and polypeptides of Bcl-B, for the modulation of apoptosis and treatment of apoptosis related diseases. Lead Inventor John C. Reed, M.D....]]>Fri, 22 May 2009 16:22:35 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2596http://burnhamott.technologypublisher.com/technology/2595 Assays           Apoptosis - Diagnostics - Immunology and Inflammation - Signal Transduction - Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel methods to identify paraptosis regulators as an alternative to apoptotic cell death.   Lead Inventor Dale Bredesen, M.D.   Selected ReferencesList of references via P...]]>Fri, 22 May 2009 16:22:35 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2595http://burnhamott.technologypublisher.com/technology/2594 Peptides           Apoptosis - Cancer - Diagnostics - Infectios Disease - Therapeutics   Polypeptides of the bacterial Bcl-2 domain to regulate apoptosis in host and bacterial cells.    Lead Inventor Adam Godzik, Ph.D. Godzik lab homepage   Selected References List of references via Pubmed   Patent Information Full title: Bacterial Bcl-...]]>Fri, 22 May 2009 16:22:34 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2594http://burnhamott.technologypublisher.com/technology/2593 Biologicals          Apoptosis - Cancer - Immunology & Inflammation - Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing  novel SUMO specific proteases found in bacteria, as therapeutic virulence targets.   Lead Inventor Adam Godzik, Ph.D. Godzik lab homepage   Selected Refer...]]>Fri, 22 May 2009 16:22:34 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2593http://burnhamott.technologypublisher.com/technology/2592 Peptides                        Cancer- Diagnostics- Reproduction -Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel polypeptide substrates that target specific matrix metalloproteinases during pathological angiogenesis.   Lead Inventor Jeffrey Smith, Ph.D. Smith l...]]>Fri, 22 May 2009 16:22:34 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2592http://burnhamott.technologypublisher.com/technology/2591 Assays           Apoptosis - Cancer - Diagnostics - Post Translational Modifications -  Signal Transduction  - Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing a novel  method of screening prostate epithelial cells for neoplastic activity, to identify compounds that change neoplastic activity or cause apoptosis in those cells, for staging c...]]>Fri, 22 May 2009 16:22:34 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2591http://burnhamott.technologypublisher.com/technology/2590 Assays           Apoptosis - Cancer - Immunology and Inflammation - Infectious Diseases - Metabolic Diseases - Neurobioloy  - Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel methods of identifying apoptosis modulators for the treatment of diseases with characteristic apoptosis defects such as cancer, Alzheimer’s disease, autoimmune and infectious diseases.  ...]]>Fri, 22 May 2009 16:22:33 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2590http://burnhamott.technologypublisher.com/technology/2589 Peptides                               Assays - Cancers - Diagnostics - Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel peptides that home to breast vasculature for the treatment of cancer. Background A major obstacle in treating cancer is the relative lack ...]]>Fri, 22 May 2009 16:22:33 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2589http://burnhamott.technologypublisher.com/technology/2588 Biologics                                                 Cancer - Therapeutics Inhibitors of ATF2 activity to treat cancer.   Lead Inventor Ze’ev Ronai, Ph.D. Ronai lab homepage   Selected References J Biol C...]]>Fri, 22 May 2009 16:22:33 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2588http://burnhamott.technologypublisher.com/technology/2587 Peptides                        Apoptosis - Signal Transduction - Therapeutics   Peptides that bind Eph receptors, disrupting receptor-ligand interactions, to modulate the activity of Eph receptors and stimulate apoptosis.   Background The Eph receptors are a large family of receptor tyrosine kinases that regulate a multitude of biological process...]]>Fri, 22 May 2009 16:22:33 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2587http://burnhamott.technologypublisher.com/technology/2586 Biologics                Apoptosis - Cancer - Signal Transduction - Therapeutics Compounds that regulate cell attachment apoptosis (anoikis) through the Bit1/AES pathway.Lead Inventor Erkki Ruoslahti, M.D., Ph.D.Ruoslahti lab homepageSelected ReferencesList of references via PubmedPatent InformationClick here for patent Full title: Methods of Modulating Cell Death Based on the BIT-1/AES Regul...]]>Fri, 22 May 2009 16:22:32 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2586http://burnhamott.technologypublisher.com/technology/2585 Biologics                    Therapeutics - Signal Transduction - Neurobiology A method of inducing a synergistic neuroprotective effect through the erythropoietin and insulin like growth factor pathways.   Lead Inventor Stuart Lipton, M.D., Ph.D. Lipton lab homepage   Selected References J Neurosurg. 2009 Jul;111(1):164-70. Fletcher, L. ...]]>Fri, 22 May 2009 16:22:32 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2585http://burnhamott.technologypublisher.com/technology/2584 Biologicals           Cancer   Compounds that modulate phosphoinositide 3 related kinases to modulate cell cycle control and DNA damage check points.   Lead Inventor Robert Abraham, Ph.D.   Selected References Cancer Res. 1998 Oct 1;58(19):4375-82. Sarkaria, JN. et al.   Patent Information Click here for paten...]]>Fri, 22 May 2009 16:22:32 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2584http://burnhamott.technologypublisher.com/technology/2583 Small Molecule Compounds           Assays - Signal Transduction - Stem Cell Biology   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel inhibitors of the Shp2 pathway to modulate stem cell self renewal, differentiation, survival and expansion.   Lead Inventor Gen-Sheng Feng, Ph.D. Feng lab homepage   Selected Refer...]]>Fri, 22 May 2009 16:22:32 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2583http://burnhamott.technologypublisher.com/technology/2582 Peptides           Apoptosis - Immunology and Inflammation - Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel peptides that can modulate apoptosis and inflammation through interactions with the death domain fold, a tertiary structure motif common to apoptotic and inflammatory proteins. Lead Inventor Adam Godzik, Ph.D. Godzik lab homepage ...]]>Fri, 22 May 2009 16:22:31 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2582http://burnhamott.technologypublisher.com/technology/2581 Diagnostics                                      Biomarker - Cancer - Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel methods of quantifying inhibitors of apoptosis proteins (IAP) as a biomarker to diagnose and determine the prognosis of pro...]]>Fri, 22 May 2009 16:22:31 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2581http://burnhamott.technologypublisher.com/technology/2580 Biologicals          Cancer - Cardiovascular Disease - Therapeutics   The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel beta lactone compounds that inhibit fatty acid synthase (FAS) for the treatment of cancer and other cell proliferation diseases.   Lead Inventor Jeffrey Smith, Ph.D. Smith lab homepage   ...]]>Fri, 22 May 2009 16:22:31 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2580http://burnhamott.technologypublisher.com/technology/2579 Peptides           Diagnostics - Neurobiology - Signal Transduction - Therapeutics   Functional NR3B peptides for the detection of excitatory glycine receptors ligands, agonists, antagonists and for the treatment of neurological disorders.   Lead Inventor Stuart Lipton, M.D., Ph.D. Lipton lab homepage   Selected References List of publications via Pubmed   Patent Information...]]>Fri, 22 May 2009 16:22:31 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2579http://burnhamott.technologypublisher.com/technology/2578 Peptides                                              Cancer - Therapeutics     The Sanford-Burnham Medical Research Institute is seeking a company interested in commercializing novel peptides that home to the lymphatic vasculature of tumors for the treatment of cancer metastas...]]>Fri, 22 May 2009 16:22:30 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2578http://burnhamott.technologypublisher.com/technology/2577 Biologics                    Neurobiology - Signal Transduction - Therapeutics Compounds that modulate the NMDA (N-methyl-D-aspartate) receptor subunit, NR3A to treat neurological conditions.Lead InventorNobuki  Nakanishi, Ph.D.Nakanishi lab homepageSelected ReferencesJ Neurophysiol. 2008 Jan;99(1):122-32. Tong, G. et al.Patent InformationClick here for patent Full ...]]>Fri, 22 May 2009 16:22:30 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2577http://burnhamott.technologypublisher.com/technology/2576 Assays              Methods of labeling molecules to detect interaction by nuclear magnetic resonance spectroscopy.   Lead Inventor Maurizio Pellecchia, Ph.D. Pellecchia lab homepage   Selected ReferencesList of references via Pubmed   Patent Information Full title: Use of selective Trp labeling to detect and characterize ligand...]]>Fri, 22 May 2009 16:22:30 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2576http://burnhamott.technologypublisher.com/technology/2575 Peptides                                         Cancer - Diagnostics - Therapeutics   Peptides that selectively home to the vasculature of pre-malignant skin lesions.   Lead Inventor Erkki Ruoslahti, M.D., Ph.D. Ruoslahti lab homepage   Selected References ...]]>Fri, 22 May 2009 16:22:30 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2575http://burnhamott.technologypublisher.com/technology/2574 Small Molecule Compounds                                                        Cancer - Therapeutics     Compounds of wortmannin analogs to treat vascular restinosis, a major long term complication that can occur after surgical ...]]>Fri, 22 May 2009 16:22:29 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2574http://burnhamott.technologypublisher.com/technology/2573 Biologics           Apoptosis - Cancer - Signal Transduction - Therapeutics A method of enhancing apoptosis in neoplastic cells by inhibiting the Survivan pathway. Lead Inventor John C. Reed, M.D., Ph.D. Reed lab homepage Selected References EMBO J. 2003 Jun 2;22(11):2729-40. Marusawa, H. et al. Patent information Click here for patent   Full Title: Use of hepatitis B X-int...]]>Fri, 22 May 2009 16:22:29 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2573http://burnhamott.technologypublisher.com/technology/2572 Peptides                                   Cardiovascular Disease - Therapeutics   Peptides that home to the heart and surrounding vasculature for the treatment of heart disease.   Features ·         Targets coronary vasculature   Background Cardiovascular di...]]>Fri, 22 May 2009 16:22:29 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2572http://burnhamott.technologypublisher.com/technology/2571 Small Molecule Compounds           Infectious Diseases - Therapeutics   Compounds that inhibit the lethal factor of the anthrax bacillus.   Features ·        Inhibits the lethal factor protease function of anthrax   Background Anthrax disease is caused by the bacterium Bacillus anthracis. It is rarely lethal during the common cutaneous infection ...]]>Fri, 22 May 2009 16:22:29 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2571http://burnhamott.technologypublisher.com/technology/2570 Biologics                             Assays - Infectious Diseases - Therapeutics An open reading frame in the cyclic AMP kinase of the SARS coronavirus as a potential target for SARS treatment.Features Treatment for severe acute respiratory syndrome Background The coronaviruses are members of a family of enveloped viruses that replicate ...]]>Fri, 22 May 2009 16:22:29 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2570http://burnhamott.technologypublisher.com/technology/2569 Biologics                    Assays - Immunology - Therapeutics Methods of treating autoimmune disorders through the identification of single nucleotide polymorphisms in lymphoid tyrosine phosphatases.Features Materials and methods for autoimmune disease research, diagnostic and therapeutic strategies Background B and T lymphocytes are the main mediators of the cellular imm...]]>Fri, 22 May 2009 16:22:28 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2569http://burnhamott.technologypublisher.com/technology/2568 Small Molecule Compounds           Assays - Metabolic Diseases - Therapeutics     Compounds that modulate Shp2 activity for the treatment of body weight disorders.   Features ·         Levels of body fat can be stabilized ·         Minimal side effects   Background Obesity is a major concern ...]]>Fri, 22 May 2009 16:22:28 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2568http://burnhamott.technologypublisher.com/technology/2567 Biologics                           Infection Diseases - Therapeutics Inhibitors of protein tyrosine phosphatases for the treatment of plague caused by Yersinia species.Features Non-antibiotic treatment for Y. pestis infection Reverse the strong inhibitory effects of YopH on T cell activation  Rescue T cells from YopH-ind...]]>Fri, 22 May 2009 16:22:28 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2567http://burnhamott.technologypublisher.com/technology/2566 Biologics          Glycobiology - Infectious Diseases - Therapeutics Antimicrobial carbohydrates for the treatment of ulcers caused by Helicobacter pylori infections. Features Gastric ulcer, duodenal ulcer and gastritis treatment A non-antibiotic treatment option BackgroundThe acidic environment of the stomach is ideally suited to breaking down food to release its nutrients for absorption in the intestine. T...]]>Fri, 22 May 2009 16:22:28 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2566http://burnhamott.technologypublisher.com/technology/2565 Biologics                                             Cancer - Therapeutics Metadherin, a novel cell-surface protein in breast tumors that mediates lung metastasis. Features Tumor metastasis is inhibited Background Tumor metastasis is a complex process where cancer cells ...]]>Fri, 22 May 2009 16:22:27 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2565http://burnhamott.technologypublisher.com/technology/2564 Small Molecule Compounds                                           Neurobiology - Therapeutics     Compounds that can inhibit matrix metalloproteinases (MMPs) to treat neurological disorders.   Features ·         MMPs are effectivel...]]>Fri, 22 May 2009 16:22:27 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2564http://burnhamott.technologypublisher.com/technology/2563 Small Molecule Compounds           Neurobiology - Therapeutics   Compounds to treat anxiety disorders through the inhibition of potential anxiety response modulators.   Features ·         Inhibit or prevent psychiatric disorders   Background Two regions of the brain, the hippocampus and amygdala, have been implicated in conditioned fear behavi...]]>Fri, 22 May 2009 16:22:27 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2563http://burnhamott.technologypublisher.com/technology/2562 Assays          Cancer - Therapeutics   A method for the high throughput screening of protein kinase B inhibitors (PKB) for potential cancer treatments.   Features ·         Inhibits protein kinase B (Akt) ·         Potential breast, ovarian and prostate cancer treatment   Background  Protein phos...]]>Fri, 22 May 2009 16:22:27 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2562http://burnhamott.technologypublisher.com/technology/2561 Stem Cell Biology                                           Neurobiology - Therapeutics   A method of generating homogenous neural precursors from human embryonic stem cells (hESCs) suitable for use in a clinical setting.   Features ·         ...]]>Fri, 22 May 2009 16:22:26 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2561http://burnhamott.technologypublisher.com/technology/2560 Small Molecule Compounds                                         Bone Disorders - Therapeutics   Compounds that modulate tissue non-specific alkaline phosphatases (TNAPs) to treat vascular calcification and other disorders.     Features ·     ...]]>Fri, 22 May 2009 16:22:26 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2560http://burnhamott.technologypublisher.com/technology/2559 Small Molecule Compounds                                               Cancer - Therapeutics Compounds that inhibit melanoma cell growth and treat melanomas.   Features ·         Sensitizes melanoma cells to apoptosis ...]]>Fri, 22 May 2009 16:22:26 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2559http://burnhamott.technologypublisher.com/technology/2558 Small Molecule Compounds                                                            Apoptosis   Compounds that inhibit cell death caused by endoplasmic reticulum stress.   Features ·   &nb...]]>Fri, 22 May 2009 16:22:26 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2558http://burnhamott.technologypublisher.com/technology/2557 Peptides                           Cancer - Neurobiology - Therapeutics   Modulators of amyloid beta peptides for the treatment of neurodegenerative diseases and cancers.   Features ·         Modulation of amyloid beta peptide levels   Background Approximately 20 million people...]]>Fri, 22 May 2009 16:22:25 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2557http://burnhamott.technologypublisher.com/technology/2556 Peptides                                    Reproduction - Stem Cell Biology  Peptides that enhance human embryo implantation and sperm motility. Features ·                Male fertility is enhanced ·        &n...]]>Fri, 22 May 2009 16:22:25 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2556http://burnhamott.technologypublisher.com/technology/2555 Small Molecule Compounds                   Cardiovascular Disease - Immunology - Therapeutics   Compounds that inhibit the TOR (target of rapamycin) pathway for the treatment of metabolic syndromes.   Features ·         Prevents age related heart function decline ·         Increases...]]>Fri, 22 May 2009 16:22:25 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2555http://burnhamott.technologypublisher.com/technology/2554 Peptides                                                 Cancer - Therapeutics   Peptides that inhibit Dickkopf (Dkk) proteins for the treatment of cancers.   Features ·         Can be used for stem cell prolifer...]]>Fri, 22 May 2009 16:22:25 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2554http://burnhamott.technologypublisher.com/technology/2553 Small Molecule Compounds           Diagnostics - Neurobiology - Therapeutics   Compounds to activate cellular antioxidant pathways (HO-1) for neuroprotection in instances of trauma, ischemia and hypoxia.   Features ·        Electrophilic compounds that can accumulate specifically in neuronal cells   Background Cellular ...]]>Fri, 22 May 2009 16:22:24 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2553http://burnhamott.technologypublisher.com/technology/2552 Stem Cell Biology           Cell Culture A method of dissociating human embryonic stem cells (hESCs) to single cells for expansion and propagation of hESCs. Features ·         Generation of clonal ESC colonies ·         Efficient and effective   Background Stem cells are pluripotent cells capable of generating almost a...]]>Fri, 22 May 2009 16:22:24 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2552http://burnhamott.technologypublisher.com/technology/2551 Small Molecule Compounds                                      Muscular Dystrophy - Therapeutics   Compounds that modulate the ubiquitin ligase, RNF-5 (ring finger 5), for the treatment or prevention of muscular dystrophy.   Features ·        RNF5 knockout mouse MD ...]]>Fri, 22 May 2009 16:22:24 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2551http://burnhamott.technologypublisher.com/technology/2550 Assays           Biomarker - Cancer - Diagnostics - Therapeutics   A method of prognosing and treating breast cancer based on matrix metalloproteinase 26 (MMP) expression.   Features ·         Biomarker for diagnosing, prognosing and treating breast cancer   Background Breast cancer is the most common type of cancer in Western women and affects millions worldwide. Ne...]]>Fri, 22 May 2009 16:22:23 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2550http://burnhamott.technologypublisher.com/technology/2549 Peptides                                Cancer - Wound Healing - Diagnostics    Peptides that specifically target wounds and tumors for diagnosis and treatment.   Features Targets wounds, tumors and blood clots Useful for imaging and delivering chemotherapeutic agents Background Chemotherapeut...]]>Fri, 22 May 2009 16:22:23 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2549http://burnhamott.technologypublisher.com/technology/2548 Stem Cell Biology           Cell Culture - Defined Media   A method to derive primitive endoderm-like cells for the pluripotent culture of mammalian embryonic stem cells.   Features ·         Methods of isolating and culturing primitive endoderm like cell lines ·         Efficient, feeder-free hESC culture methods   ...]]>Fri, 22 May 2009 16:22:23 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2548http://burnhamott.technologypublisher.com/technology/2547 Small Molecule Compounds           Cancer - Therapeutics   Compounds of Cyclosporin A used to sensitize tumor cells to TNF family death receptors.   Features ·         Can be used to treat diverse range of cancers, including, breast, lung, and colon, etc ·         Can be used in combination with TRAIL and tumor vaccines  ...]]>Fri, 22 May 2009 16:22:23 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2547http://burnhamott.technologypublisher.com/technology/2546 Small Molecule Compounds           Cardiovascular Disease - Singal Transduction - Therapeutics   Modulators of the R-RAS signal transduction pathway in vascular remodeling and differentiation.   Features ·        Cell proliferation and migration are inhibited ·        Cellular differentiation is facilitated   ...]]>Fri, 22 May 2009 16:22:22 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2546http://burnhamott.technologypublisher.com/technology/2545 Peptides              Post Translational Modifications   Features ·        Alternative proteosome dependant polypeptide degradation pathways can be investigated   Background The eukaryotic cell cycle is coordinated in sequential steps mediated by protein degradation. Protein degradation is, in turn, mediated by ubiquitination, or tagging of proteins, for proteosome dest...]]>Fri, 22 May 2009 16:22:22 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2545http://burnhamott.technologypublisher.com/technology/2544 Peptides                                        Cancer - Diagnostics  - Therapeutics   Peptides that target lymphatic vessels in tumors for early diagnosis and treatment.   Features ·         Specifically home to tumor lymph systems · &n...]]>Fri, 22 May 2009 16:22:22 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2544http://burnhamott.technologypublisher.com/technology/2543 Assays                                    Diabetes   A method for screening compounds that modulate insulin production for the diagnosis and treatment of diabetes.   Features ·        Identification of compounds that increase or decrease insulin production  ...]]>Fri, 22 May 2009 16:22:21 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2543http://burnhamott.technologypublisher.com/technology/2542 Small Molecule Compounds           Diabetes - Diagnostics - Therapeutics   Compounds that inhibit matrix metalloproteinases (MMPs) for the treatment of type 1 diabetes.   Features ·         Immobilization of T cells entering islets   Background A central role in insulin dependent diabetes mellitus (Type 1), a T cell mediated autoimmune disorder, is p...]]>Fri, 22 May 2009 16:22:21 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2542http://burnhamott.technologypublisher.com/technology/2541 Peptides                                     Reproduction - Therapeutics   Peptides that target endometriosis cells for the diagnosis and treatment of endometriosis.   Features ·                Specific targeting of ectopically located ...]]>Fri, 22 May 2009 16:22:21 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2541http://burnhamott.technologypublisher.com/technology/2540 Biologics Methods and compounds related to the ileal bile acid binding protein (IBABP) for the diagnosis and treatment of colorectal cancer. Features Non-invasive diagnostic tool Useful during early stages of colorectal cancer BackgroundColorectal cancer is the third most prevalent malignancy in the United States. Currently, the most widely used non-invasive test is the fecal occult blood test (FOBT). The FOBT has been used for more than thirty ye...]]>Fri, 22 May 2009 16:22:21 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2540http://burnhamott.technologypublisher.com/technology/2539 Small Molecule Compounds           Apoptosis - Cancer- Infectious Diseases - Therapeutics   Compounds to inhibit fatty acid synthase for use as a cancer therapeutic.   Features ·         Non-competitive reversible inhibitor ·         Causes tumor cell death ·         Can also inh...]]>Fri, 22 May 2009 16:22:20 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2539http://burnhamott.technologypublisher.com/technology/2538 Small Molecule Compounds           Apoptosis - Cancer - Diagnostics - Therapeutics   Compounds that sensitize death receptors for the treatment of cancer.   Features · Cells may not acquire resistance to the identified compounds compared to current recombinant protein based protocols · The compounds can alter both extrinsic and intrinsic apoptosis pathways · Targets multiple cancers (breast...]]>Fri, 22 May 2009 16:22:20 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2538http://burnhamott.technologypublisher.com/technology/2537 Small Molecule Compounds                       Cancer - Infectious Disease - Therapeutics   An inhibitor of hematopoietic protein tyrosine phosphates (HePTP) to treat disorders such as leukemia.   Features Downregulates HePTP  Augments activation of Erk1/2 and p38 Background Protein tyrosine phosphatases (PTPs) are...]]>Fri, 22 May 2009 16:22:20 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2537http://burnhamott.technologypublisher.com/technology/2536 Small Molecule Compounds           Cancer - Diagnostics - Signal Transduction - Therapeutics   Compounds that inhibit the PI3 K-AKT-mTOR kinase signal transduction pathway to treat various disorders, such as cancer.   Features Specifically targets the signal transduction pathway of the PI3-K-AKT-mTOR pathway Background The phosphoinositide 3-kinase (PI3/AKT) pathway is a potent mediator ...]]>Fri, 22 May 2009 16:22:20 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2536http://burnhamott.technologypublisher.com/technology/2535 Stem Cell Biology                                                      Cancer - Biomarkers   A stem cell intrinsic transcription factor gene, ZNF206, which maintains stem cell pluripotency and regulates self renewal.   Features ...]]>Fri, 22 May 2009 16:22:19 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2535http://burnhamott.technologypublisher.com/technology/2534 Small Molecule Compounds           Cardiovascular Disease -Diagnostics - Therapeutics   Compounds that inhibit TNAP activity for the treatment of vascular calcification, arterial calcification and cardiovascular disease.   Features  Effectively inhibits TNAPs at physiological pH levels Background Many cardiovascular diseases involve tissues such as arteries and heart valves bec...]]>Fri, 22 May 2009 16:22:19 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2534http://burnhamott.technologypublisher.com/technology/2532 Small Molecule Compounds           Infectious Diseases - Therapeutics   Compounds that inhibit proprotein convertases to treat or prevent viral or bacterial infections.   Features Broad spectrum treatment for viral and bacterial pathogens Background Pathogens or their toxins, including hemorrhagic fever and influenza viruses, botulinum, pseudomonas and anthrax toxins, require processing by h...]]>Fri, 22 May 2009 16:22:19 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2532http://burnhamott.technologypublisher.com/technology/2531 Software and Instruments              A hybrid annotation and publication system for peer review, annotation and publication of information from a database.   Features Users can access the annotation and publication system via a web browser Content is stored in a hierarchical manner Background Wiki-style programs allow users to edit and publish content, but alone are limited to the content acce...]]>Fri, 22 May 2009 16:22:18 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2531http://burnhamott.technologypublisher.com/technology/2530 Assays           Cancer - Diagnostics - Therapeutics   A method to reduce bile acids to treat colorectal cancer.   Features Alternative diagnostic method to the FOBT Can treat colorectal cancer by reducing bile acids Background Colorectal cancer is the third most prevalent malignancy in the United States. Currently, the most widely used non-invasive test is the fecal occult...]]>Fri, 22 May 2009 16:22:18 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2530http://burnhamott.technologypublisher.com/technology/2529 Small Molecule Compounds           Cancer - Diagnostics - Signal Transduction - Therapeutics   Compounds that bind Eph receptors to diagnose, prognose or monitor Eph receptor related diseases.   Features Specific binding of Eph receptors Background The Eph receptors are a large family of receptor tyrosine kinases that regulate many biological processes during development and in adult tissues, by ...]]>Fri, 22 May 2009 16:22:18 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2529http://burnhamott.technologypublisher.com/technology/2527 Assays                                        Cancer - Diagnostics - Therapeutics   A method to diagnose and monitor prostate cancer for the early diagnosis of prostate cancer, to monitor the disease and course of treatment, and to determine the grade of prostate cancer.   Featur...]]>Fri, 22 May 2009 16:22:18 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2527http://burnhamott.technologypublisher.com/technology/2526 Nanoparticle                                      Cancer - Diagnostics - Therapeutics   Compounds that selectively target tissues and amplify their own homing ability to cells or tissues.   Features Selective targeting of tumors Amplification of homing signal Background Nano...]]>Fri, 22 May 2009 16:22:17 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2526http://burnhamott.technologypublisher.com/technology/2525 Assays           Diagnostics - Neurobiology - Therapeutics   A method for identifying early markers of neurodegenerative disorders to detect and monitor neurodegenerative diseases such as Alzheimer’s, Parkinson’s, dementia and stroke.   Features Early detection of neurodegenerative disease Can be used to assess the effectiveness of treatment Background Clinical biomarkers can be used to ...]]>Fri, 22 May 2009 16:22:17 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2525http://burnhamott.technologypublisher.com/technology/2524 Peptides                                  Cancer - Diagnostics - Therapeutics  Peptides that can be selectively targeted to regenerating tissue and tumors for the treatment of injuries, surgical sites, cancers and inflammatory disorders. Features Selective targeting of wounds and tumors. Healing and tissue regeneration ...]]>Fri, 22 May 2009 16:22:17 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2524http://burnhamott.technologypublisher.com/technology/2523 Small Molecule Compounds           Cancer - Signal Transduction - Therapeutics   The current invention provides compounds that inhibit the AKT signaling pathway to inhibit tumor growth.   Features Decreases AKT expression Decreases tumor size  Background The AKT signaling pathway is a key tumor survival mechanism. AKT activation can cause phosphorylation of close to one hund...]]>Fri, 22 May 2009 16:22:17 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2523http://burnhamott.technologypublisher.com/technology/2521 Peptides                                              Reproduction - Therapeutics   Peptides that selectively target endometriosis cells to diagnose, track the progression of, and treat endometriosis.   Features Selective targeting of endometriosis cells Background ...]]>Fri, 22 May 2009 16:22:16 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2521http://burnhamott.technologypublisher.com/technology/2518 Small Molecule Compounds           Diagnostics - Infectious Diseases - Therapeutics   The current invention is a compound that inhibits anthrax lethal factor (LF) protease for use as a potential therapeutic.   Features Specifically inhibit LF Potentially uses against the botulinum toxin  Background The development of new therapeutics against anthrax and botulinum n...]]>Fri, 22 May 2009 16:22:15 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2518http://burnhamott.technologypublisher.com/technology/2517 Small Molecule Compounds           Cancer - Immunology and Inflammation - Therapeutics   Compounds to inhibit protein receptors (RAGE) for the treatment of inflammation and cancer.   Features Targets specific anti-inflammatory and anti-cancer activity Background Cancer is diagnosed in more than 1 million people every year in the United States alone.  In spite of numerous adva...]]>Fri, 22 May 2009 16:22:15 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2517http://burnhamott.technologypublisher.com/technology/2516 Stem Cell Biology           Therapeutics - Cardiovascular disease Compounds to promote cell division and differentiation of human stem cells. Features ·        Promotes cell division and differentiation Background Stem cells are pluripotent cells that have the capacity to differentiate into cells of all types, including heart, bone, neurons and cardiomyocytes. They could be a valuable source for ...]]>Fri, 22 May 2009 16:22:15 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2516http://burnhamott.technologypublisher.com/technology/2515 Assays                                                                  Cancer   A method for high throughput screening to identify inhibitors of proteases.   Features · &...]]>Fri, 22 May 2009 16:22:15 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2515http://burnhamott.technologypublisher.com/technology/2514 Stem Cell Biology                                             Neurobiology - Therapeutics   Compounds used during stem cell differentiation to mitigate cell death during neuralization.   Features Numbers of neural precursor cells can be greatly increased Feeder...]]>Fri, 22 May 2009 16:22:14 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2514http://burnhamott.technologypublisher.com/technology/2513 Stem Cell Biology                            Neurobiology - Therapeutics   The current invention is a method of differentiating neural crest cells from stem cells for use as tools to study neural crest cells and develop therapies for neural crest related disorders.   Features A normally transient population of cells can now be studied...]]>Fri, 22 May 2009 16:22:14 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2513http://burnhamott.technologypublisher.com/technology/2509 Assays           Diabetes - Therapeutics   A method for screening insulin production modulators and compounds that induce insulin gene expression.   Features Increases insulin production Background Diabetes mellitus is a familiar disease, known to lead to morbidity and mortality. Diabetes is characterized by high blood glucose levels, which result from defects in insulin production, insulin action or both. ...]]>Fri, 22 May 2009 16:22:13 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2509http://burnhamott.technologypublisher.com/technology/2508 Small Molecule Compounds           Cancer - Diagnostics - Immunology and Inlammation - Therapeutics   Compounds of the current invention selectively inhibit the NF-kB pathway (induced by PKC activators) to treat autoimmune diseases, inflammation and cancer.   Fetaures Specifically inhibits the NF-kB pathway induced by PKC activation Background Dysregulation of NF-kB activity cont...]]>Fri, 22 May 2009 16:22:13 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2508http://burnhamott.technologypublisher.com/technology/2507 Assays                                             Signal Transduction   A method for assaying ubiquitination and identifying modulators of ubiquitination to regulate aberrant signal transduction.   Features ·        Multi-well array ...]]>Fri, 22 May 2009 16:22:12 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2507http://burnhamott.technologypublisher.com/technology/2505 Peptides                           Inmmunology and Inflammation - Therapeutics   Compounds to inhibit NOD-like receptors, including caspase-1, useful to treat inflammation.   Advantages ·         Can be used to perform drug screening assays ·         ...]]>Fri, 22 May 2009 16:22:12 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2505http://burnhamott.technologypublisher.com/technology/2503 Assays                              Apoptosis  - Cancer - Biomarker  - Therapeutics   A method of profiling Bcl-B in tumors to monitor or select therapies for cancer treatment.   Features ·         Can be used to predict the severity of cancers ·     &n...]]>Fri, 22 May 2009 16:22:11 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2503http://burnhamott.technologypublisher.com/technology/2502 Assays           Cardiovascular Disease - Diagnostics - Therapeutics   A method of preparing fruit fly hearts to study cardiac related genes and to screen new drugs and treatments for cardiac diseases and disorders.   Features Semi-automated analysis allows a number of parameters to be quantified simultaneously Single gene defects can be studied  Background Cardiovascular disea...]]>Fri, 22 May 2009 16:22:11 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2502http://burnhamott.technologypublisher.com/technology/2500 Peptides                                 Cancer - Diagnostics - Therapeutics   Compounds that can be selectively targeted and selectively internalized into cells and tissues, such as tumors.   Features Selective targeting of various cell types and tissues including tumor Identifying those cells and tissues fo...]]>Fri, 22 May 2009 16:22:11 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2500http://burnhamott.technologypublisher.com/technology/2498 Assays                                      Cancer   A screening assay to identify SMIPs and compounds identified in the assay for use as cancer treatments.   Features Effectively identifies SMIPs Provides compounds that inhibit p27 depletion The compo...]]>Fri, 22 May 2009 16:22:10 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2498http://burnhamott.technologypublisher.com/technology/2496 Software and Instruments              A method of automated, multiplanar microscopy for imaging biological specimens.   Features ·        Multiple focal planes can be acquired simultaneously   Background During automated scanning cytometry, stage movement, specimen illumination and image acquisition must be automated by a host computer. To c...]]>Fri, 22 May 2009 16:22:10 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2496http://burnhamott.technologypublisher.com/technology/2495 Small Molecule Compounds                                     Aging - Therapeutics   Compounds of doxycycline, selenium, and zinc to prolong survival or treat symptoms of aging.   Features Retards or reduces physiological age related changes Prolongs survival ...]]>Fri, 22 May 2009 16:22:10 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2495http://burnhamott.technologypublisher.com/technology/2494 Small Molecule Compounds                                          Bone Disorders - Therapeutics   Compounds that modulate TNAP activity to treat bone mineralization disorders.   Features The compounds may be used to effectively treat various bone mineralization ...]]>Fri, 22 May 2009 16:22:09 GMTccurchoe@burnham.orghttp://burnhamott.technologypublisher.com/technology/2494